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In pre-marketing clinical studies of brand-name Wellbutrin SR (sustained-release bupropion) in the treatment of major depressive disorder, mild weight loss of greater than five pounds occurred in 28% of all patients receiving the medication at either a dose of 300 mg per day or 400 mg per day

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It was reduced by semaglutide, which prompted further evaluation of anti-inflammatory properties of semaglutide in an acute in vivo inflammation model