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*Correspondence: Donato Cappetta, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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However, with the substance administered weekly, the reaction may be more pronounced in the first weeks, especially with rapid dose escalation, but most symptoms subside as the body adapts