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10.1016/j.foodchem.2023.137108 Food Chem

These molecules can accumulate and cause damage to cellular structures in their search to become stable, leading to a range of health issues

Vascular edema (accumulation of extracellular water due to increased blood-brain barrier permeability) and cytotoxic edema (disruption of Na+/K + pump function on the cell membrane) are considered the underlying mechanisms of HACE (Bailey et al., 2009)