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GLP-1R V229A internalised more slowly than WT receptor after exendin-4 stimulation (Figure 6A-C), with only 10% of V229A internalised after 5-minutes stimulation versus 30% for WT

PMID: 40789979 | doi:10.1007/s12178-025-09990-7 DeFoor MT et al

Dehydration worsens nausea and contributes to constipation, another common side effect

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This already translates into sales as PepsiCo and Mondelez saw a decline of 2% and 4.1% of their revenue in North America in the first quarter of this year