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Although one study showed that tirzepatide did not affect the risk of diabetic retinopathy in patients with type 2 diabetes mellitus, however, there is still a need for large-scale randomized controlled trials are needed to assess the long-term safety of tirzepatide with respect to the risk of diabetic retinopathy ( A Korean study on antidiabetic drugs revealed significant sex differences, with females reporting more ADEs than males ( Our study analyzed the temporal relationship between drug administration and ADE onset time

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The advantage of this work is that it partially addresses the prevailing general limitations encountered during the coupling of unprotected amino acids, including self-condensation (giving 6-membered diketopiperazines), sequential inversion, cyclisation, and over-reaction (Figure 4a)