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Glycaemic efficacy is enhanced when these agents are used together, with clinical trials demonstrating HbA1c reductions typically around 10-20 mmol/mol (1-2%) from baseline, depending on starting values and specific agents used

Rapid weight loss without proper nutrition support can negatively impact muscle mass, metabolic function, and bone health

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Other potential side effects include stomach pain, bloating, gas, and headache

The appetite-suppressing effects of semaglutide GLP-1 usually become noticeable within a few weeks after initiating the treatment