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CJC-1295 is a synthetic analogue of Growth Hormone-Releasing Hormone (GHRH) with tetrasubstituted modifications (D-Ala, Gln, Ala, Leu) that protect the peptide from degradation by the enzyme DPP-IV, thereby extending its half-life relative to native GHRH

CJC-1295 offers more modest but potentially more sustainable effects by working within the body's natural systems

Vomiting, diarrhoea, constipation, bloating, and reflux can also occur

The first GLP-1 agonistsintended to treat T2Dcame onto the market almost two decades ago

Methods Medline, Embase and Cochrane CENTRAL were searched for randomized controlled trials (RCTs) on tirzepatides weight loss efficacy for these patients