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Cancer Risk A review and discussion stated: ROS production is significantly increased in cancer cells because of mitochondrial dysfunction, altered metabolism, and frequent genetic mutations, resulting in an accumulation of large amounts of oxidized protein, DNA, and lipids as an adaptive response, cancer cells harbor elevated levels of ROS-scavenging molecules

[21] [22] Clinical significance [edit] Patients with mutations in the GSS gene develop glutathione synthetase (GSS) deficiency, an autosomal recessive disorder

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doi: 10.1136/gutjnl-2017-314508