Canada has become the first major Western market where generic semaglutide can be legally manufactured and sold, subject to Health Canada approval
This involved adding more protein, fibre, healthy fats, and vegetables to their diet, as well as increasing hydration levels, especially on days when eating was difficult
On one hand, it can degrade intestinal mucin glycoproteins by enzymes (such as glycoside hydrolases, proteases, sulfatases, and sialidases) to produce SCFAs, acetates, propionates, and 1,2-propanediol, as well as succinates and sulfates, promoting mucin turnover and thickening, thereby enhancing intestinal barrier function and reducing the permeability of gut microbiota products
doi:10.1007/s13300-018-0535-9 19
Lower doses are considered off-label and lack systematic evidence for weight maintenance