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In certain embodiments, any controlled-release otic formulation described herein increases the exposure of an active agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 100%, or higher than 100%, compared to an otic formulation that is not a controlled-release otic formulation

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Electrical stimulation of neocortical layer 1 results in a GABA A -receptor-mediated PSC in pyramidal neurons

PlexusDx offers both forms, and injection delivery is far more forgiving regarding meal timing

This ensures it is appropriate for your specific health profile and that any potential side effects can be managed