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Although a plethora of tumor cell mechanosensors have been identified, including focal adhesions, ion channels, actin cytoskeleton, nuclear proteins, and transcription factors, more research is needed to uncover how breast cancer cells convert biophysical signals into biochemical cues to mediate short- and long-term mechanoresponses ( Table 5 )

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FIGURE 6 8 Tissue biomarkers of renal toxicity Several biomarkers were elevated in the kidney after vitamin E supplementation in rodents