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Two reasons in the documented cadence
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Tau-induced activation of glial cells increases the expression of EC adhesion molecules, facilitating leukocyte migration across the BBB [165]
"Patients taking tirzepatide are advised to switch to a non-oral contraceptive or add a barrier method of contraception for four weeks after first taking the medicine and for four weeks after each increase in the dose." The safety alert also noted no GLP-1-type medication should be used during pregnancy
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