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Strain Route of Administration Dose Period of Administration Parameter Investigated Reference Intramuscular injection 2 g/rat Single dose Number and optical density of IL-2-positive cells in hypothalamic structures [97] Intranasal 2g/rat 0.5 g/rat Every 12 h (2 days) C-Fos protein content in pineal gland [89] 20 ng/rat Single dose Cortical neuron activity [100] C-Fos and IL-2 content in hypothalamic structures [90] Orally 100 mg/rat 14 days Body weight and activities of membrane-bound digestive enzymes [92] 100 g/rat 1 month Body weight and activities of subepithelial membrane-bound digestive enzymes [93] Microinjection into the intercellular medium of neocortex 0.5 L of 1011 MSingle dose Cortical neuron activity [100] No data 2 g/kg 4 days Inuence on premature aging of reproductive functions [98] LIO Subcutaneous injection 0.1 g/rat

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Radiat Oncol