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Additionally, we calculated AUC for ratings across timepoints

doi: 10.1001/jama.2021.1831 103 CowartK

A Unique Side Effect: Dysesthesia One unusual symptom stood out: Dysesthesia, an unpleasant skin sensation, occurred in up to 20.9% of high-dose users Placebo rate: 0.7% Most cases were mild, and few caused patients to stop treatment, but this is something clinicians will watch closely as more data emerge

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Dosage control : Some users may require a specific dose that is easier to adjust with injections than with a pre-measured patch