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The rationale is mechanistic extrapolation, not demonstrated synergy
Furthermore, APOE4 is associated with a decrease in the basal membrane area and an increase in thrombin concentrations in the vessel walls [144, 153]
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Knockdown of NNMT in adipocytes was associated with increased NAD+ levels and altered expression of genes involved in energy expenditure, providing the rationale for pharmacological NNMT inhibition [2]
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