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Description AOD9604 (Metabolic Research Peptide) AOD9604 is a synthetic peptide analogue derived from the C-terminal region of human growth hormone (specifically residues 177-191), modified with an additional tyrosine residue at the N-terminus

The depletion of NADPH directly leads to a decrease in GSH levels, inactivates GPx4, and prevents the clearance of intracellular LPO, eventually causing the accumulation of LPO

The chosen concentration was also consistent with those reported in previous studies investigating transplacental transport, which used similar concentrations, and even exceeded, using up to 1,000 g/mL of PS-MP in cell lines ( The observed increase in cytotoxicity confirms the findings from several studies demonstrating PS-MNP cytotoxicity in pregnant mice and their offspring ( In addition to increased cytotoxicity, PS-MP exposure induced humungous levels of reactive oxygen species (ROS), such as O 2 and H 2 O 2

S.et al (2021)

No controlled GLOW trial establishes a results timeline