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Tirzepatide is frequently listed among the best peptides for weight loss as a once-weekly dual agonist of the GLP-1 and GIP receptors, making it the first clinically validated twincretin for obesity and type 2 diabetes

277 Some other drug strategies under development are outlined in Table 1

A person with multiple risk factors may benefit more from aggressive medical management

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Additionally, the gene expression of endothelial nitric oxide synthase (eNOS), neuronal nitric oxide synthase (nNOS), and inducible nitric oxide synthase (iNOS) was assessed via qPCR