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SGLT2is were initially developed as glucose-lowering drugs and were noted to have beneficial effects on systolic BP and weight reduction

b , Plasma aspartate aminotransferase (AST) activity

That means the researchers cant definitively prove that GLP-1s were behind these apparent mental health benefits

The study was funded by research on the association between genetic polymorphism of GLP1R and the efficacy of GLP1 analogues [grant numbers 201602171] and a comprehensive clinical evaluation study of GLP-1RA [grant numbers 2024YZ002]