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When inflammation becomes persistent: Ongoing inflammation can disrupt the skin barrier, slow healing, and increase the likelihood of acne marks and uneven skin tone over time

doi: 10.1016/j.autrev.2012.02.013 508 KleinRBergP

A patient may start at a low dose and increase gradually under provider guidance

The effort needed to optimize these regimens can be experienced as aversive, promote frustration, and generate a desire to avoid such effort, aligning with a region of the brain called the anterior midcingulate cortex, as described by Lisa Feldman Barrett and colleagues