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Head and neurological effects Tirzepatide headaches are common in the first few weeks and often reflect dehydration more than direct medication effects

1 Introduction Glucagon-like peptide-1 (GLP-1) is an incretin hormone released from gut enteroendocrine cells and regulates blood sugar by increasing insulin while reducing glucagon secretion and inhibiting stomach emptying and food intake (Drucker, 2022)

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The cosmetic effect of rapid fat reduction has led to increased interest among patients in corrective dermatological treatments, including dermal fillers and skin-tightening procedures [11,22]

GLP-1RAs approved for use in the treatment of T2DM include semaglutide, liraglutide, and dulaglutide