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Certainty of Evidence for 15% Weight Loss Since the 15% weight loss threshold is clinically meaningful for obesity management, we applied the GRADE approach to our NMA estimates, following the method described by Yepes-Nuez et al

Clin Chim Acta (2011) 412:103642.10.1016/j.cca.2011.02.021 115 MelnykSFuchsGJSchulzELopezMKahlerSGFussellJJet alMetabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism

And while these treatments have been shown to be effective in supporting significant amounts of weight loss and improvements in health status, there also may be a risk of losing skeletal muscle mass