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Penzel et al., 2015)

Menthol: Rapid pain relief Menthol activates cold receptors (TRPM8) located in the skin and nerve endings, producing a refreshing cooling sensation

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Filter-sterilize through a 0.22 m low-protein-binding filter before introduction into sterile cell culture, and prepare working dilutions immediately before use

These patients also exhibit polymorphisms to the serotonin receptor 2A region of chromosome 13 and the human leukocyte antigen region of chromosome 6, as well as abnormalities in catechol- O -methyltransferase