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Safety considerations : Caution is needed for individuals with a history of thyroid cancer, gastrointestinal disorders, or kidney issues
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Hydroxocobalamin, the form of B12 most commonly used in UK clinical practice, may cause a harmless pink or red discolouration of urine
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Second, NNMT depletes that universal methyl donor, SAM, which is essential for DNA methylation, neurotransmitter production, and other indispensable biological processes
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