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The most robust clinical evidence arguably originates from the large cardiovascular outcomes trials (CVOTs) completed for most GLP-1 RAs, of which the latest showed a significant relative risk reduction (RRR) of 39% (HR) with once-weekly efpeglenatide on HF requiring hospitalisation, corroborating a meta-analysis which found a significant RRR across eight GLP-1 RA CVOTs of 11%

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[DOI] [PubMed] [Google Scholar] 125.van der Pol A., Gil A., Tromp J., Sillj H.H.W., van Veldhuisen D.J., Voors A.A., Hoendermis E.S., Grote Beverborg N., Schouten E.M., de Boer R.A., et al