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Found mainly in animal products like meat, dairy, and eggs, its often challenging for those with dietary restrictions or absorption issues to maintain optimal levels through diet alone

Safety and Tolerability: Oral supplements have the mildest side effect profile, with almost no side effect profile in most people

Deficiency of VMAT2 elevates monoamine turnover, evidenced by reduced levels of DA, norepinephrine, 5-hydroxytryptamine and histamine in catecholaminergic neurons, leading to up-regulation of amine-synthesizing enzymes [23]

A systematic review and meta-analysis established a significant, dose-dependent relationship between elevated circulating TMAO levels and increased risk of AF [63]

control group: n = 458