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doi: 10.1042/BSR20211299 54 MurzynA.KrasowskaA.StefanowiczP.DziadkowiecD.ukaszewiczM
The abdominal cavity of rats was opened to remove the entire small intestine from the pylorus to the cecum, and the mesenteric fat and intestinal contents were removed
The views and opinions of the author(s) do not reflect those of the US Army or the Department of Defense
The model was defined by two differential equations: A and C are the amounts of drug in the depot and central compartments, k a and k el are the first-order absorption and elimination rate constants, V/F is the volume of distribution, F is the bioavailability (assumed equal to one), and Cp is the drug concentration in the central compartment
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