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doi: 10.1016/j.molmet.2018.05.012 15 TumminiaAVinciguerraFParisiMFrittittaL

Conversely, by "cognitive dysfunction" we mean the loss of such abilities

78 Augmented cAMP signaling might not only strengthen classical cAMP/PKA pathways but could also modulate cAMP/Epac-dependent pathways, including PI3K/Akt, which have been associated with aspects of cellular survival, mitochondrial bioenergetics, and autophagy in preclinical studies

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It is reported that in the Phase I study assessing the safety, tolerability, pharmacokinetics, and pharmacodynamics of the drug, 98 patients with type 2 diabetes who had been continuously taking metformin were randomly assigned to receive either a placebo or PF-06882961