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The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels

Lancet Diabetes Endocrinol 10(9):634644

Oral formulations need higher doses to produce the same blood levels the injectable achieves at lower doses - and higher doses mean higher manufacturing costs

It has documented independent effects on lipid panels that show up in lab work, often within the first few months of treatment

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