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However, after a 12-week treatment with E2, liver ER expression significantly increased in ovariectomized compared to sham-operated rats receiving the same treatment, suggesting that long-term estrogen replacement may lead to enhanced hepatic estrogen responsiveness, although this phenomenon is yet to be demonstrated in estrogen-deficient humans receiving estrogen replacement (25)

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Minimally, the average half-life in dogs was 4.0 +/- 0.7 minutes

The weight-reducing properties arise from multiple mechanisms, most notably the modulation of appetite and satiety signals in the central nervous system