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RYBELSUS is not recommended in patients with severe gastroparesis Hypersensitivity: Serious hypersensitivity reactions (e.g., anaphylaxis, angioedema) have been reported in patients treated with RYBELSUS
In some cases, patients may need to discontinue their medication if its not working to manage their diabetes or its contributing to problematic side effects
It is a safety requirement because tirzepatide activates GIP receptors that semaglutide never touched
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(MP4 3429 kb) Studies investigating the mechanism of action of GLP-1RA therapy for causing weight loss provide evidence that GLP-1RA treatment is associated with reductions in appetite and hunger, lower preference for energy-dense foods, alteration in food reward pathways, decrease in food cravings, and improvement in eating control (Table 2) [25, 26, 33, 34]
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