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No peer-reviewed clinical studies, pharmacokinetic interaction data, or regulatory guidance exist on the combined use of AOD 9604 and retatrutide

Proton-pump inhibitors (e.g., omeprazole, esomeprazole, and lansoprazole), used to treat Zollinger-Ellison syndrome and gastroesophageal reflux disease (GERD), markedly decrease stomach acid secretion required for the release of vitamin B 12 from food but not from supplements

However, nearly 30% of patients eventually develop drug-refractory epilepsy, which significantly affects the quality of life and psychological health of patients, posing a major societal burden [1]

Epileptogenic activity of sodium-folate and the blood brain barrier in the rat