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276 Tirzepatide is associated with significantly greater proportion of achieving MASH remission with no worsening of fibrosis compared with placebo 277 in a phase 2 trial, and another phase 2 trial for dual agonism of glucagon receptor and GLP-1R (GCGR/GLP-1RA) survodutide demonstrated similar improvements in MASH

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On the other hand, lower glutathione levels can be associated with impaired immune cell activity

The resultant modified E residues are -carboxyglutamate ( gla )