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Nine children were not allowed to continue to Phase 2

Seier S, Pedersen J, Lymperis K, Balck J, Gudbergsen H

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Glutamine is degraded into ammonia in the intestine and kidneys, achieving its partial excretion.15 At the level of the brain, hyperammonemia conditions an increase in glutamine synthetase activity, and by exceeding the metabolic capacity of the astrocyte, conditions intracellular osmolarity alterations with later edema, cytolysis, and proinflammatory cytokine release