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doi: 10.1038/leu.2015.174 522 HedgerMPde KretserDM

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Accelerated Tau deposition in the brains of individuals infected with human immunodeficiency virus-1 before and after the advent of highly active anti-retroviral therapy

This was an unanticipated finding since TMAO is associated with cardiovascular and metabolic disease and AD and prior human studies showed modulation of plasma TMAO by the E4 allele ( APOE also influences L-carnitine metabolism following challenge and whether this impacts GBB and/or TMAO levels