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The authors reported that AOD-9604 stimulated lipolysis in isolated adipocytes and that chronic daily treatment in obese Zucker rats produced reductions in body weight gain of more than 50% relative to untreated controls over the treatment period, without effects on insulin sensitivity or IGF-1 levels [3]

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Changes in mitochondrial dynamics may be an adaptive response of tumor cells to environmental stressors such as acidosis and hypoxia, which are closely related to the disruption of mitochondrial function 39

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