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The exact mechanism by which colchicine may exert anti-atherothrombotic effects is not fully understood

Collectively, these results highlight the ability of highly engineered apocynin derivatives to specifically inhibit the NOX2 isoform at its mitochondrial source, while substances such as GKT137831 support the more general NOX inhibition strategy to reduce vascular and tissue-specific ROS in fibrotic diseases and diabetic nephropathy

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2009;60(Suppl 7):161165