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(2014) 6(1):e968490

doi: 10.1016/j.jad.2020.03.121

The association between the extent of systemic exposure to isotretinoin and risk of recurrence after completion of a course of isotretinoin therapy has been established, with fewer relapses observed in patients who received a cumulative dose of conventional isotretinoin of 120 to 150mg/kg, 8,12,29 suggesting that there may be a minimal threshold of systemic exposure necessary to produce prolonged therapeutic effects after stopping treatment

& Shaughn OBrien, P

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