Summer brings its own considerations
Divry, P., Roulaud-Parrot, F., Dorche, C., Zabot, M
Consequentially, delicate interactions among amino acids are altered
Unusual Amino Acids And Modifications Non-natural amino acids, PEGylation, cyclization, and C- or N-terminal modifications all add synthesis steps and specialty reagents
The total number of proteins that bind calcium is beyond the scope of this discussion but several important examples of intracellular Ca 2+ -binding proteins include the calmodulins, calcineurins, calbindins, and troponins, whereas important extracellular Ca 2+ -binding proteins include the coagulation factors [II (prothrombin), VII, IX, X, protein C, protein S] and the cell-cell communication/adhesion proteins of the cadherin family