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Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress

Each sample was resuspended in 20 l of LC/MS grade water and 10 l per sample was injected into a 5500 QTRAP, a hybrid triple quadrupole/linear ion trap mass spectrometer, using a quantitative polar metabolomics profiling platform with selected reaction monitoring (SRM) that covers all major metabolic pathways

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Lancet (1999) 354(9180):7401.10.1016/S0140-6736(99)02479-4 13 NyholmETurpinPSwainDCunninghamBDalySNightingalePet alOral vitamin B12 can change our practice

Nai et al