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Trimethylamine N-oxide impairs -cell function and glucose tolerance

Multiple sclerosis (MS) MS is an autoimmune disease characterized by inflammation and demyelination of the central nervous system, leading to progressive neurodegeneration and worsening of symptoms [186]

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While PIASs are able to associate with STATs, they are also able to regulate other transcription factors including SMADs, androgen receptor, c-JUN, and p53

These include vitamin B 12 deficiency, mutations of the MTHFR gene, and epigenetic modifications that alter expression of other key enzymes involved in folate metabolism