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313 In AD mouse models, NNT expression is reduced, 314 and the activities of key metabolic enzymes, such as aconitase, -KG dehydrogenase, and malic dehydrogenase (MDH), are inhibited, 315,316 further impairing energy metabolism and antioxidant capacity

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These modifications can lead to mutations, genomic instability, and if not adequately repaired, contribute to carcinogenesis and other genetic disorders [39]