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In cancers such as lung cancer, endothelial dysfunction can promote tumor growth and metastasis through various mechanisms [188,189,190]

[7] Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene

No obvious toxicity has been reported in rodent studies at effective doses

I was like, I got a train to get ready for it

No major randomized controlled trial has demonstrated superior outcomes or acceptable tolerability for combining these two monotherapies, which is why standard-of-care guidelines recommend dose optimization of a single agent first