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The PCAC evaluates nominations partly on demonstrated clinical needdocumented clinical use cases carry weight
That includes questions like whether the dose meaningfully helps, how it affects appetite and metabolism over time, This is especially concerning for people without obesity or a diabetes diagnosis, because the potential benefits are less clear while the medical risks still exist
doi: 10.3389/fphar.2025.1663717 Received 11 July 2025 Accepted 29 August 2025 Published 15 September 2025 Volume 16 - 2025 Edited by Suresh Kumar Mohankumar, Swansea University Medical School, United Kingdom Reviewed by Wahyu Widowati, Maranatha Christian University, Indonesia Iman Nabilah Abd Rahim, Universiti Teknologi MARA (UiTM), Malaysia Updates Copyright 2025 El Rabey, Attia, Bakry, Rezk and Sharfeldin
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