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( A ) Resmetirom, a synthetic, liver-targeted, selective thyroid-hormone-receptor- (THR-) agonist, consists of a tri-substituted benzyl ether core in which (i) two iodine atoms present in T3 are replaced by polar, non-halogen substituents (a trifluoromethyl group and a cyano group), and (ii) the hydrophobic phenolic ring of T3 is replaced by a 3,5-dichloro-4-(4-cyano)phenyl moiety

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