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HepG2 cells, transfected with human CYP2E1-expressing gene, (E47 cells) have been established to study CYP2E1-dependent ethanol hepatotoxicity [122, 22]

Long-term exposure to pollutants like microplastics (MPs) and DEHP promotes excessive ROS production through the CNR1/CRBN/YY1/CYP2E1 axis, oxidizing YAP1, which ultimately leads to necroptosis and impaired ovarian function in granulosa cells (Wu H

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