Additionally, the same detox and metabolism triggered by the above can also cause a partial histamine breakdown and trapping of methylhistamine which can aggravate all the Sx you mention as well
Biochem Pharmacol 164:3444 Pereira M, Jeyabalan J, Jorgensen CS, Hopkinson M, Al-Jazzar A, Roux JP, Chavassieux P, Orriss IR, Cleasby ME, Chenu C (2015) Chronic administration of glucagon-like peptide-1 receptor agonists improves trabecular bone mass and architecture in ovariectomised mice
Other important considerations: Gallbladder disease GLP-1 receptor agonists, particularly when causing rapid weight loss, may increase the risk of gallstones and gallbladder inflammation
Mike posted on social media back in 2020 that hes 56, so well have to take his word for it
Sterility, remember, is paramount