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a 2025 literature review identified limited clinical evidence, including a retrospective study of 12 patients with knee pain and a Phase I trial in healthy volunteers whose results were not submitted

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MAO : a gene that requires B2 as a cofactor, is slower in men and reduces tyramines, histamine, and catecholamines (stress neurotransmitters)

During pregnancy, factors that contribute to oxidative stress include: Hormonal Changes : Elevated hormone levels can increase metabolic activity, leading to more ROS production

Decreased bloodbrain barrier P-glycoprotein function in the progression of Parkinsons disease PSP and MSA