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Clinical trials show average weight loss of approximately 5 to 8 percent of body weight meaningful, but significantly less than newer agents

That said, "no serious toxicity in animal models" is not the same as "proven safe in humans long-term," and anyone with a personal or family history of cancer should treat the angiogenic mechanism above as a genuine reason to talk to a qualified clinician before starting

doi: 10.3390/cells11213400 47 CheY.HouL.SunF.ZhangC.LiuX.PiaoF.et al

We pay particular attention to any contraindications, such as a history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2