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# 1706404, Bio-Rad) in Tris-buffered saline (TBS) (50 mM Tris, 150 mM NaCl, pH 7.5) containing 0.05% (wt/vol) Tween 20 (TBST) at room temperature

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(h) Telomere alteration : POT1 is a component of the shelterin complex regulating telomere stability (47), and was unchanged by GlyNAC or placebo supplementation

Other Therapies Clinical studies have also demonstrated a modest benefit for other pharmacological treatments including venlafaxine (Effexor), tramadol (ConZip), amitriptyline (Elavil), opioids, oxcarbazepine (Trileptal), and topical amitriptyline, baclofen, lidocaine, or ketamine, as well as non-pharmacological treatments including massage, non-invasive neuromodulation, acupuncture/acupressure, and aromatherapy (Dan 2024)

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