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These combination data support the hypothesis that dual targeting of amylin receptor and GLP-1 receptor pathways which engage anatomically and mechanistically distinct neural circuits can produce synergistic metabolic outcomes in preclinical and clinical models

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Researchers often call this investigational pairing CagriSema. Studies have examined it for effects on appetite, energy intake, body weight, and metabolic control in adults with overweight or obesity, including some populations with type 2 diabetes

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